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2002騫?0鏈?銆?鏃ュ湪緹庡浗鍦ｅ湴浜氬摜涓捐鐨勨?a target=_blank>鍥介檯騫茬粏鑳?yōu)鍜屽啀鐢熷屨d鐨勫鏈爺絀跺強鍟嗗姟搴旂敤澶т細鈥濅笂鑱氶泦浜嗘潵鑷淗arvard Medical School鈥? 鈥淭he Salk Institute鈥? 鈥淪tanford University School of Medicine鈥濈瓑涓栫晫涓婁竴嫻佸ぇ瀛﹀拰鐮旂┒闄㈢殑涓撳銆佸鑰咃紱榪樻湁鈥淎dvanced Cell Technology鈥? 鈥淐entocor鈥? 鈥淕eron鈥? 鈥淟ayton鈥濈瓑涓栫晫涓婃渶钁楀悕鐨勭敓鐗╂妧鏈叕鍙哥殑楂樺眰浜哄憳鍏?00澶氫漢銆備笌浼氱殑榪樻湁澶氬悕閾惰鎶曡祫瀹躲佸緥甯堝強緹庡浗鎬葷粺鐢熺墿縐戞妧欏鵑棶鍥㈢殑浠ｈ〃銆?/p>
鍦ㄤ細璁紑濮嬩箣鍓?鎸夌収鎯緥錛屾瘡浣嶄笌浼氫笓瀹墮兘棰嗗埌浜嗕竴鏈ぇ浼氭眹緙栵紝鍏朵腑鍖呭惈鏈浼氳鐨勬墍鏈夊唴瀹癸紝鍏朵腑寰愭暀鎺堢殑婕旇鍐呭鍗犲叏閮ㄥ唴瀹圭殑1/3錛?5欏?190欏碉級銆傜敱姝ゅ彲瑙侊紝澶т細鐨勪笓瀹跺鍛樹細鍜岀粍緇囪呭MEBO緇勭粐鍣ㄥ畼鍐嶇敓澶嶅埗瀛︽湳鍜屾妧鏈潪甯擱噸瑙嗐傛嬈′細璁叡閭璇峰崄浣嶅浗闄呰憲鍚嶇殑鐢熷懡縐戝瀹朵綔澶т細涓婚鍙戣█錛屽緪鑽ｇゥ鏁欐巿鏄叾涓殑縐戝瀹朵箣涓銆備負浜嗚涓庝細鑰呮洿鍔犺緇嗗湴浜嗚В鏌愪簺婕旇涓撻錛屼細璁涓変釜縐戞妧灞曞彴錛屼細璁紑濮嬩箣鍓嶏紝鍑犱箮鎵鏈夌殑涓庝細浠ｈ〃灝卞凡緇忛兘鍏夐【浜嗏淢EBO縐戞妧鈥濆睍鍙幫紝鎵鏈夌粍緇囧櫒瀹樺師浣嶅拰浣撳澶嶅埗鎶鏈祫鏂欒涓鎶㈣岀┖銆傚緢澶氶闄╂姇璧勫鍑睄榪欎簺璧勬枡鍧囦笌鎴戜滑闆嗗洟寤虹珛浜嗘姇璧勮仈緋匯?
姝ゆ浼氳鐨勫鏈笓棰樺唴瀹瑰垎涓ら儴鍒嗭紝絎竴閮ㄥ垎鏄共緇嗚優(yōu)銆佸熀鍥犳妧鏈強緇嗚優(yōu)鐤楁硶錛涚浜岄儴鍒嗘槸鐢熸畺鍏嬮殕鍜屽櫒瀹樺啀鐢熷尰瀛︼紱絎竴閮ㄥ垎琚畨鎺掑湪10鏈?鏃ヨ繘琛岋紝絎簩閮ㄥ垎鍦?鏃ヨ繘琛屻?0浣嶄富棰樺彂璦浜哄垎鍒悜澶т細鎶ュ憡浜嗗悇鑷殑鏈鏂扮爺絀舵垚鏋溿備互GERON鍏徃鍓富甯璂avid EarpJ.D.涓轟唬琛紝鎬葷粨鍜屼粙緇嶄簡浠栦滑鑷猅HOMASION寮濮嬭繘琛岀殑鑳氳儙騫茬粏鑳?yōu)鐮斀I跺強鍏惰繘灞曟儏鍐碉紝浣嗙洰鍓嶇殑鐮旂┒浠嶅仠鐣欏湪騫茬粏鑳?yōu)鐨勫煿鍏婚樁娈靛Q屽湪姝ら樁孌靛皻鏈揪鍒板湪浣撳鍩瑰吇鎴愭湁鍔熻兘鐨勭粍緇囧櫒瀹樼殑闃舵銆傚湪鍩哄洜鎶鏈殑鎺㈣棰嗗煙錛孡ayton Bioscience鐨凙nnemarie Moseley浠嬬粛浜嗚漿鍩哄洜鐢熸畺鍩瑰吇鐨勭爺絀舵垚鏋滐紝浣嗕篃灝氭湭鑾峰緱浜轟綋搴旂敤鐨勭獊鐮淬傚湪緇嗚優(yōu)鐤楁硶棰嗗煙錛屽瀹跺ぇ瀛﹀潎鍦ㄤ笉鍚岃搴︽姤鍛婁簡鍦ㄧ緇忕粏鑳?yōu)鍜尲湠缁従l嗚優(yōu)鐤楁硶絳夋柟闈㈢殑鐮旂┒錛屼絾浠嶆湭鑾峰緱涓村簥紿佺牬錛屽鍝堜經澶у鐨凟van Y. Snyder鏁欐巿浠嬬粛鐨勭緇忓共緇嗚優(yōu)鐨勭爺絀跺強鈥滃彲鑳解濈殑娌葷枟鍓嶆櫙錛屽綋鏈変唬琛ㄩ棶閬撳叾鍙兘鐨勨淭ime table鈥濇椂錛屼粬璋堝埌鏈鏃╀篃鏄湪2-3騫翠箣鍚庯紱The Salk Institute鐨凞ieter 涔熻鍒頒簡浠栦滑鍦ㄦ垚浣撶緇忓共緇嗚優(yōu)鐨勭爺絀訛紝涓嶮EBO鐨勫墠鏈熸濊礬寰堟帴榪戯紝浣嗕粬浠篃寰堥毦紿佺牬浣撳鍩瑰吇緇嗚優(yōu)鎴愪負緇勭粐榪欎竴鍏籌紱鍦ㄧ敓孌栧厠闅嗙爺絀朵笂錛屽湪鍥介檯涓婂洜鐜囧厛鐮旂┒浜虹被鑳氳儙鍏嬮殕鑰岀煡鍚嶇殑ACT鍏徃涓誨腑Micheal錛岃緇嗕粙緇嶄簡鍔ㄧ墿鍜屼漢綾昏儦鑳庡厠闅嗙殑鎶鏈拰鏂規(guī)硶銆傝繕鏈夊嚑浣嶈憲鍚嶇殑縐戝瀹禢aohiro Terada銆乀im Brazelton銆丣an W銆丮. Wisser閮藉ぇ鑳嗗湴鍦ㄧ敓鍛界瀛﹀墠娌跨爺絀剁殑澶氫釜姒傚康鍜屾湭鏉ョ殑鍖誨鍙婄瀛﹀墠鏅柟闈㈡彁鍑轟簡璁炬兂鍜岀湅娉曪紝濡? Stanford University School of Medicine 鐨凾im Brazelton閫氳繃浠栬嚜宸辯殑瀹為獙鏁版嵁鍙婅繎騫存潵涓栫晫鑼冨洿鍐呯殑鐮旂┒鎯呭喌錛屽ぇ鑳嗗湴鎻愬嚭鐜版湁鐨勫共緇嗚優(yōu)姒傚康宸叉棤娉曡窡涓婅繘灞曪紝騫舵彁鍑轟簡鍏朵慨鏀瑰悗鐨勬柊姒傚康鑼冪暣銆?/p>
鍦ㄧ粍緇囧櫒瀹樺師浣嶅拰浣撳鍐嶇敓澶嶅埗鐨勭爺絀跺拰搴旂敤涓撻涓婏紝MEBO鍥介檯闆嗗洟钁ｄ簨灞涓誨腑寰愯崳紲ユ暀鎺堝叕甯冧簡瀹炲疄鍦ㄥ湪鐨勭幇瀹炵粨鏋滐紝鏃犺鏄粠緇嗚優(yōu)瀛︾爺絀訛紝榪樻槸鍘熶綅緇勭粐鍣ㄥ畼鍐嶇敓澶嶅埗鍙婂凡瀹屾垚鐨勪復搴婂簲鐢ㄧ粨鏋滐紝鍧囨兜鐩栦簡澶т細鐨勬墍鏈変富棰樺唴瀹廣傚緪鏁欐巿鍦ㄧ煭鐭?0鍒嗛挓閲岋紝綆媧佸湴浠嬬粛浜嗏滃啀鐢熷尰瀛︹濈殑鑳屾櫙鍜屾濊礬銆佹柟娉曞強緹庡疂鍦ㄨ儍鑲犵矘鑶溿佽儼鑵恒佹瘺鍥娿佺毊鑲ょ瓑鍘熶綅鎴栦綋澶栧啀鐢熷鍒剁殑鐮旂┒榪涘睍錛屼互鍙婄敤MEBO-鈪℃不鎰堢毊鑲ょ檶鐨勪復搴婅祫鏂欙紝騫墮噸鐐逛粙緇嶄簡鐨偆鍣ㄥ畼鍘熶綅鍐嶇敓澶嶅埗娌葷枟鐑т激涓殑閲嶅ぇ鎴愭灉銆傛墍鏈夌殑涓庝細浠ｈ〃浠兘琚粬鐨勫彂璦鎵娣辨繁鍚稿紩錛岀瀛﹀浠負鍐嶇敓鍖誨鐨勬彁鍓嶅埌鏉ヨ屾劅鍒版縺鍔紱涔熸湁鐨勭瀛﹀褰撶湅鍒版垜浠叕甯冪殑緇撴灉鏃訛紝鎯呬笉鑷鍦拌嚜璇細鈥滅湡鐨勬槸榪欐牱錛熷氨榪欎箞綆鍗曪紵闅句互緗俊錛佲?/p>
鏉ヨ嚜UCSD鐨勬暀鎺圗wa
Carrier鍦ㄥ彂璦緇撴潫鍚庢縺鍔ㄥ湴璇達細鈥滄垜璁や負浣犱滑鐨勬濊礬闈炲父姝ｇ‘錛屽茍涓斿綋澶у閮藉湪鎺㈢儲璇ュ浣曡蛋鐨勬椂鍊欙紝浣犱滑宸茬粡鐧諱笂浜嗛氬線鎴愬姛鐨勫垪杞︼紝鐪熺殑錛屼綘浠凡緇忔嬁鍒頒簡閽ュ寵錛佷綘浠殑鍙戣█鏄垜鍦ㄦ嬈″ぇ浼氫笂鐨勬渶澶ф敹鑾鳳紒鈥?
鏉ヨ嚜Centocor鐨凷enior Scientist鈥斺旀潹闈欓珮鍏村湴璇達細鈥滅湅鍒版垜浠腑鍥戒漢鑳藉仛寰楄繖涔堝ソ錛岃繙榪滈鍏堜笘鐣屾渶鍏堣繘姘村鉤錛屾垜鐪熶負鎴戞槸涓浗浜鴻岃嚜璞紒鈥?/p>
鏈夌殑縐戝瀹跺寰愭暀鎺堣錛屸滄槸涓撻棬鏉ュ惉浣犵殑鎶ュ憡鐨勶紝鍥犳兂鐩存帴浜嗚В涓┒绔熲濄傛潵鑷猆C澶у鐨勬暀鎺堣錛氣滄槰澶╄緇嗙湅浜嗘眹緙栫殑鏉愭枡錛岃涓轟綘浠殑璺墠鏄紜殑錛屾墍浠ワ紝浠婂ぉ鎴戜滑鍙堜笓紼嬫潵鍚姤鍛婏紝鎴戜滑鎰挎壙鎺ヤ綘浠殑楠ㄩ珦鍐嶇敓鐮旂┒銆傗?/p>
鍑犱箮鎵鏈夌殑浜洪兘鍦ㄩ棶錛氣滃湪鍝兘涔板埌浣犱滑鐨勭粍緇囧櫒瀹樺鍒朵駭鍝?鈥濆嚑涔庢墍鏈夌殑鍏跺畠鍏徃浠ｈ〃閮藉湪闂細鈥滀綘浠槸鎬庝箞鎵懼埌緇勭粐鍣ㄥ畼鍘熶綅鍐嶇敓鐨勭敓鍛藉啀鐢熺墿璐ㄧ殑錛熲濆嚑涔庢墍鏈夌殑浜洪兘鍦ㄨ璁哄悓涓涓瘽棰樷滅粍緇囧櫒瀹樺啀鐢熲斺擬EBO銆丮EBO-鈪°丮EBO-鈪⑩︹︹? 鐢氳嚦榪炰細璁粍緇囪呴兘鍛婅瘔鎴戜滑錛氣滃鏋滄垜鐑激浜嗭紝鎴戝喅涓嶅湪榪欓噷鐪嬪尰鐢燂紝鎴戜細椋炲埌涓浗鍘繪壘浣犱滑錛佲?/p>
澶т細緇勭粐濮斿憳浼氫富甯復琛屽墠錛岃鍒板緪鏁欐巿錛岀洓鎯呴個璇峰緪鏁欐巿鏄庡勾澶忓ぉ鍑哄腑絎笁灞婂浗闄呭共緇嗚優(yōu)鍙婂啀鐢熷尰瀛︿細璁傚緪鏁欐巿鎰夊揩鍦版帴鍙椾簡閭璇楓?/p>
寰愭暀鎺堢殑鎶ュ憡錛屼笉浠呬負鍩虹鐢熷懡縐戝瀹剁殑鐮旂┒鎻愪緵浜嗘柊鐨勭爺絀舵濊礬錛屼篃鎻愬墠瀹炵幇浜嗕漢浠湡鐩肩殑鈥滅粍緇囧櫒瀹樺啀鐢熷尰瀛︹濄?
姝ｅ澶т細涓誨腑鈥斺擠oros Platika (CENTAGENTIX鐨凜EO) 鎵璇寸殑鈥滅帺絎戣瘽鈥濓細鈥滅敓鐗╁熀紜瀛﹀浠涔堥兘鎳傦紝浣嗕粈涔堥兘涓嶄細鍋氾紱澶栫鍖葷敓浠涔堥兘浼氬仛錛屼絾浠涔堥兘涓嶆噦錛岋紱鐥呯悊瀛﹀浠涔堥兘鎳傦紝涔熶粈涔堥兘浼氬仛錛屼絾宸蹭負鏃跺お鏅氾紱鍙湁鍐嶇敓鍖誨鐢熷懡縐戝瀹朵粈涔堥兘鎳傦紝涔熶粈涔堥兘浼氬仛錛屽茍涓旇兘澶熷仛寰楀強鏃訛紝浠庤屼繚闅滅敓鍛藉仴搴烽暱瀵匡紒鈥?/p>
榪欐浼氳鐨勫鏈拰鍒涙柊鎶鏈皵姘涘緢嫻擄紝縐戝瀹朵滑鍦ㄧ爺絀朵笂閮芥槸浜夊厛鎭愬悗錛岃屾病鏈変換浣曚漢浠ヨ嚜宸辯殑瑙佽瘑鍘誨惁瀹氬埆浜虹殑瑙佽В錛屽摢鎬曟槸璁炬兂銆傜湡姝ｄ綋鐜頒簡鐧懼浜夐福鐨勭瀛﹀椋庯紝浼氳鐨勪富棰樻紨璁茶呴兘鏄笘鐣岄椈鍚嶇殑縐戝瀹訛紝鑰岃繖浜涚瀛﹀鍧囧悓姣忎竴浣嶄笌浼氳呬竴鏍鳳紝浠庝笉涓鴻嚜宸辮繃鍘繪墍鍙栧緱鐨勬垚鏋滆岃嚜灞咃紝鏇存病鏈変換浣曞闇稿椋庛?
鍦ㄨ繖浜涚敓鍛界瀛﹀鐨勭溂涓紝浣滀負浠ュ疄鐜扮殑縐戝緇撴灉涓烘爣鍑嗙殑鐮旂┒錛岀編瀹濇棤鐤戞槸涓棰楁渶鑰鐪肩殑鏄庢槦錛佹垜浠腑鍥藉彂鏄庡垱绔嬪拰鎻愬墠瀹為獙鎴愬姛鐨勨滅粍緇囧櫒瀹樺師浣嶅拰浣撳鍐嶇敓澶嶅埗鈥濈殑鍐嶇敓鍖誨瀛︽湳鍜屾妧鏈凡鍦ㄤ笘鐣屽墠娌跨敓鍛界瀛︾爺絀墮鍩熺嫭鍗犵啲澶達紝榪欐槸鎴戜滑涓浗鐢熷懡縐戝瀹朵負涔嬪鏂楃殑鐩爣銆傛垜浠洿鍔犲潥淇′腑鍥界殑縐戝瀹跺拰涓栫晫鐨勭瀛﹀涔熶竴瀹氫細涓庡緪鑽ｇゥ鏁欐巿涓璧峰叡鍚屽畬鎴愪漢綾燴滅粍緇囧櫒瀹樺啀鐢熷尰瀛︹濈殑澶т笟銆傚湪涓栫晫鍚勫浗鐢熷懡縐戝瀹剁殑鍗忓悓涓嬶紝鎴戜滑緹庡疂浜烘彁鍑虹殑5騫村唴瀹炵幇206涓粍緇囧櫒瀹樺鍒剁殑縐戝鐮旂┒鐩爣錛屼竴瀹氫細鎻愬墠瀹炵幇錛佷漢綾諱篃涓瀹氫細鎻愬墠瀹炵幇浜轟漢榪囩櫨宀佺殑鍋ュ悍闀垮鐩爣錛?/p>
鏂?瀛欓湠